Touch device users, explore by touch or with swipe gestures. 3) at low temperatures has attracted much interest for high nitric oxide (NO) conversion, and this method is dominated by catalysts. D. Preventing atherosclerosis (a disease in which plaque builds up inside your arteries)Dr. These supplements contain ingredients classified as nitric oxide (NO) precursors (i. Bryan serves as Founder and CEO of Nitric Oxide Innovations, LLC, a privately-held, clinical-stage biopharmaceutical company that is actively engaged in the discovery and development of nitric oxide based therapies. A clinical, multi-site study is underway of NOi's COVID drug NOviricid, the FIRST Oral Systemic Nitric Oxide-based COVID-19 Drug. Sold by Pneuma Nitric Oxide, LLC and ships from Amazon Fulfillment. . David Perlmutter, board certified neurologist and one of the first to recognize Alzheimer’s’ disease as a metabolic disease. 23, 2020 /PRNewswire/ -- World renowned Biochemist, Dr. 75oz, 50g. 95. This review article will focus on the loss of nitric oxide production as the primary contributor to hypertension and also discuss safe and clinically proven strategies to restore nitric oxide production and recapitulate nitric oxide based signaling in humans. 00. AGE-DEFIANCE FACE CREAM. Nitric oxide (NO) has important roles in the regulation of kidney, cardiovascular and metabolic functions. Functional Nitric Oxide Nutrition is a guide to prevent disease and the signs of aging by naturally increasing N. Dr. Pneuma Nitric Oxide is the first & only anti-aging skincare serum that restores Nitric Oxide production into and on the skin to nourish, rejuvenate and reverse the signs of aging. Beetz into 2-3 ounces of water. “Our nitric oxide-generating drug, Noviricid, provides a source of nitric oxide that at-risk patients cannot make, thereby preventing the rapid progression of COVID-19. Founder and CEO. Bryan’s topical formulation, N1O1 Nitric Oxide Activating Skin Serum by Pneuma Nitric Oxide, LLC, is the first to join the Berkeley Life brand, offering a complement pairing to Berkeley Life’s current supplement. It also claims to enhance overall physical and sexual performance. Nathan S. Best Nitric Oxide Pre-Workout Supplement: Legion Pulse Pre-Workout. Guide for you that specifically addresses the questions of:The enzyme was transferred to a screw-cap style cuvette with a silicon septa lid. 4. It may increase energy levels and boosts stamina. Bryan is a successful entrepreneur and Founder of HumanN, Inc, Pneuma Nitric Oxide, LLC, Nitric Oxide Innovations, LLC. It is a dual. Correct dark spots and even skin tone. N1o1 Nitric Oxide topicals. or 4 interest-free payments of $31. Inhaled nitric oxide (iNO) results in preferential pulmonary vasodilatation and lowers pulmonary vascular resistance. Discover (and save!) your own Pins on Pinterest. Google Scholar. Nitric oxide (NO·) is an important protective molecule in the vasculature, and endothelial NO· synthase (eNOS) is responsible for most of the vascular NO· produced. N1O1 Nitric Oxide Anti-Aging Face Cream | Stimulates Collagen & Elastin | Complex Peptides & Epidermal Growth Factor | Dr. The delivery system, which supplied NO and O2 continuously by diffusion through gas permeable tubing, was found to maintain the NO and O2. Best Nitric Oxide Pre-Workout Supplement: Transparent. Weinreb RN, Ong T, Sforzolini S, et al. “It's very dramatic when you put it on because once you apply it, for the 15 to 30 minutes you get extreme basal dilation. It makes the body young by. Provides vasoactive. , “I am extremely proud and honored to announce that Dr. The route of administration delivers NO selectively to ventilated lung units so that its effect augments that of hypoxic pulmonary. These gummies are a perfect way of ingesting nitric oxide. This article discusses the possible uses of magnesium. Nathan S. N1O1 is the first anti-aging skincare that corrects the cause of your wrinkles. Pneuma Nitric Oxide LLC. Bryan, Ph. Chernoff. Ann. Nathan S. 99. Data analytics are a key part of making informed, intelligent business decisions. Bryan serves as Founder and CEO of Nitric Oxide Innovations, LLC, a privately-held. Nathan Bryan, Pneuma Nitric Oxide, LLC, Nitric Oxide Innovations, LLC and Bryan Nitriceuticals, LLC: Case Number: 1:2021cv00811: Filed: September 14, 2021: Court: US District Court for the Western District of Texas: Presiding Judge: Docket - Austin: Nature of Suit: Defend Trade Secrets Act (of 2016) Jury Demanded By: Defendant Dr. Clin Exp Dermatol 28: 511-514. The revolutionary N1O1 Nitric Oxide serum by Pneuma Nitric Oxide, is the first anti-aging skincare product to address the root cause of aging skin. Please note: Pneuma Nitric Oxide, LLC. 00. IMPROVES RECOVERY TIME. L-arginine is an amino acid, or a protein building block, naturally found in red meat, dairy products, poultry, and fish. Bryan – NEW BOOK. Briefly, as regards fractional exhaled nitric oxide, the working group recommends fractional exhaled nitric oxide as a possible adjunct measure but not as a sole measure for. Bryan says. This review demonstrates the importance of NO in both male and female reproductive processes in numerous ways, such as in. 78704. com. Nitric oxide (NO) plays multiple roles in both normal and abnormal skin processes. Garlic. However, nitric oxide ensures your muscles are replenished with nutrients and oxygen, and any lactic acid. The experience will build stronger bonds and deeper trust amongst all involved,” mentions Susan Kim Shaffer, President and Co-Founder of Pneuma Nitric Oxide. S. Corrects Wrinkles, Tone, Clarity & Texture. Softening the signs of aging. Austin, TXCircO2 is a nitric oxide supplement that improves blood flow through your vessels and removes age-related health problems like high blood pressure. You save $10 shipping per box when you get 2 boxes at a time. Pneuma nitric oxide skin serum also contains 20% Vitamin C that works synergistically with nitric oxide to help neutralize harmful free radicals and provide antioxidant support to the skin. 17, 2020 /PRNewswire/ -- A recently published study in Surgical Case Reports by Gregory Chernoff, M. Natural Ingredients for Gentle Yet Effective Cleansing: Pneuma Age-Defiance Gel Cleanser combines Antioxidants, AHA, Glycolic Acid. The past decade has witnessed an explosion in the interest of biologists in the gas nitric oxide (NO). Quite simply put, Nitric Oxide increases the body’s potential for swifter muscle mass gain and effective recovery post workout. Nathan S. Inhaled nitric oxide (iNO) has been widely used in patients with COVID-19-related acute respiratory distress syndrome (C-ARDS), though its physiological effects and outcome are debated in this setting. D CEO/FOUNDER OF NO2U & NITRIC OXIDE LEADING EXPERT Dr. N1O1 Nitric OxideTM Activating Serum with antioxidants (formerly called Pneuma) for the skin helps with: Improving the appearance of fine lines and wrinkles. Yes, N1O1 Nitric Oxide Activating Serum contains high-quality, non-allergenic ingredients. The mixture includes nitric oxide (NO), nitrogen dioxide (NO 2), nitrogen trioxide (N 2 O 3), nitrogen tetroxide (N 2 O 4), and nitrogen pentoxide (N 2 O 5). Chernoff. Dr. Nitric oxide mediates vasodilation and inhibits platelet aggregation. It is based on nitric oxide (NO), a natural nanomolecule produced by the human body with proven anti-microbial properties shown to have a direct effect on SARS-CoV-2, the virus that causes COVID-19. A topical emulsion containing equal volumes (1. It provides dedicated one-on-one time for you and each member of your staff where. Nutr Rev. 9. Nitric oxide foods are commonly leafy green, root, and cruciferous vegetables, most notably red spinach and beets. The BENEFITS are immense: Statements made have not been evaluated by the Food and Drug Administration. Researchers have developed a new gel formulation for the treatment of erectile dysfunction. 17, 2020 /PRNewswire/ -- A recently published study in Surgical Case Reports by Gregory Chernoff, M. The pharmacology, toxicity, and safety data for NO use in humans has been well-established for decades. Nitric oxide: the Ubiquitous jack of all trade. David Perlmutter, board certified neurologist and one of the first to recognize Alzheimer’s’ disease as a metabolic disease. 95 Add to. AUSTIN, Texas, Oct. Ann Rev Neurosci 10:67–95Nitric oxide (NO), the gaseous highly diffusible compound produced from the amino acid l-arginine by NO synthases, a family of Ca 2+-calmodulin-dependent iron containing enzymes (e. To explore the effect of irradiation on the nitric oxide (NO) donor-induced inhibition of oxygen consumption. Gastrointestinal issues, like vomiting and diarrhea, are the most common side effects of nitric oxide supplements, Rothstein says. A Toronto University study revealed that red spinach might support vascular health and circulation. Welcome to N1O1Skincare. R. Register now and explore the interactive floor plan of RAAD City, where you can meet the speakers, exhibitors, sponsors, and fellow attendees. In fact, we've even put together a little-known secret and Free. NO produced by endothelial cells causes vasodilatation and also inhibits platelet aggregation and leucocyte adhesion. Pneuma Nitric Oxide N101 Nitric Oxide Activating Serum ingredients explained: Water, Ascorbic Acid, Polysorbate 20, Hydroxyethylcellulose, Sodium Nitrite, Di-Tocopheryl Acetate, Dehydroacetic Acid, Benzyl Alcohol, Sodium Sulfite, Sodium Metabisulfite, Tetrasodium EDTA화학적으로 매우 반응성이 큰 물질로, 산화 되어 이산화질소 로 되기 쉽다. Int J Environ Res. Over time, if not corrected, endothelial dysfunction turns into full blown disease. XT Nitric Oxide Booster – Editor’s Choice. NO maintains vascular integrity by inhibiting platelet aggregation, 2, 3 leukocyte–endothelium. @drnathansbryan. The 20 Flow supplement gives you the required citrulline that makes the desired results and supports your health. 3. Their mission is to revolutionize the beauty industry through the development of products that produce and restore nitric oxide production in and on the human body, connecting beauty to wellness. Nathan S. Dr. These effects may contribute to improved. Nitric oxide or NO is a relatively new discovery in science and medicine. Bryan introduces N1o1, the first anti-aging skincare that uses a Nobel Prize winning discovery to defy aging skin by correcting the cause of wrinkled and damaged skin plus age spots and blemish prone skin. Our customers are consumers and professionals. Derangement of NO production is implicated in the etiology of a multitude of dermatologic diseases, indicating future therapeutic directions. D. Clinically Proven. 30 ml $245. Nitric oxide synthase. In turn, this may help lower blood pressure in some individuals ( 2 , 3 ). Upgrade Spotlight: How Nitric Oxide Controls Oxygen & Nutrient Delivery, Aging, and Quality of Life - Pneuma Nitric Oxide: 1041 (Podcast Episode 2023) Quotes on IMDb: Memorable quotes and exchanges from movies, TV series and more. Nitric oxide is a natural anti-aging molecule that decreases over time, and by age 40, the body has only about 50% of the production compared to. However, the L-Arginine it contains is the best blend that we found on the market comprising of 4 subtypes which include A. Nitric oxide (NO) is an endogenous mediator of vascular tone and host defence. It combines 7 powerful ingredients, which include L-Citrulline, L-Arginine ( AAKG ), S7™, VASO6, and several more. Decreased nitric oxide (NO) availability due to obesity and endothelial dysfunction might be causally related to the development of lifestyle-related diseases such as insulin resistance, ischemic heart disease, and hypertension. Here we update previous meta‐analyses on the effect of cocoa on. Pneuma Nitric Oxide : ASIN B0BS4F2TND : Manufacturer reference N1O1-L-2 : Date First Available. Nitric oxide is a free radical gas. Bryan is a successful entrepreneur and Founder of HumanN, Inc, Pneuma Nitric Oxide, LLC, Nitric Oxide Innovations, LLC, Bryan Nitriceuticals, LLC and Bryan Therapeutics, Inc. A 2022 review found that taking 2. N1o1 by Pneuma Nitric Oxide. In April 2019, I established Pneuma Nitric Oxide LLC, a company whose mission is to develop nitric oxide-based skincare products. So you can't put nitric oxide in a liquid. (C) demonstrated the efficacy of a topical. We’ll discuss this essential amino acid in just a bit. 00 falls apart, and we actually generate nitric oxide gas. Many employees prefer a once-a-year corporate retreat to more frequent, after-hours bonding sessions. 00 $498. This tasty drink mix encourages nitric oxide (NO) production in your vascular endothelium, the delicate inner lining of the blood vessels that is responsible for the healthy function of vital arteries. Twice Daily. Visibly reduces the appearance of wrinkles. , F. The 20 Flow. N1o1 Nitric Oxide Lozenges. In the next few minutes, you are going to discover. A Nitric oxide serum can be safely formulated without the generation of nitric dioxide and is necessary for optimal cellular health. Improves the skin’s texture & tone. The therapeutic potential of inhaled NO as a selective pulmonary. At least 50% of our daily nitric oxide production comes from our diet and oral bacteria. Enhance oxygen and nutrient delivery to cells. Janet. Nitric oxide. Nitrosigine is a patented, compound of. g. Bryan, (NOi) and Pneuma Nitric Oxide, LLC are represented by Alan Morell and Creative Management Partners (CMP), Beverly Hills, CA. O. Glaucoma is best described as an optic neuropathy characterized by slow degenerative structural changes seen in retinal ganglion cells (RGC) and the optic nerve head. Pneuma Nitric Oxide is transforming the skin care and beauty industry with their nitric oxide topical products that reduce wrinkles and fine lines, and improve complexion, clarity, and skin texture. Get a comprehensive view of the company, from pricing and customer service to product quality and more. By Dr Nathan Bryan. 9 mM, 23°C) was prepared by bubbling 6 M NaOH-scrubbed NO gas through Tris buffer. Perioperative organ injury remains a medical, social and economic problem in cardiac surgery. 1, Table 1. Released by nerve and endothelial cells in the. View Products Pneuma Nitric Oxide have developed the first nitric oxide activating serum with a dual-chamber delivery system. Support cognitive function and memory. 005% in the treatment of ocular hypertension and open angle. 00 — available on subscription Add to cart; N1o1 Nitric Oxide Lozenges $ 79. News provided by. Most recently, Dr. 1. 97 — available on subscription Add to cart. ” CHICAGO, Jan. A novel delivery system was used to study NO-mediated cyto- and genotoxicity in two human lymphoblastoid cell lines, TK6 (wild-type p53) and NH32 (p53-null but isogenic to TK6). 2). Find helpful customer reviews and review ratings for N1O1 Nitric Oxide Activating Serum with Antioxidants | Hydrating Serum For Face | Decreases Wrinkles | Pore Minimizer. Nathan Bryan, a trailblazer in the realm of biomedical research, with a specific focus on the life-sustaining molecule, nitric oxide. 1,355 likes · 7 talking about this. Since the recognition of nitric oxide (NO) as a key endothelial-derived vasodilator molecule in 1987, the field of NO research has expanded to encompass many areas of biomedical research. Said Dr. BOSTON – Inhaled nitric oxide gas widens blood vessels in the lungs and is used to treat severe cardio-pulmonary conditions in newborns and adults. Based on my research we developed Pneuma Nitric Oxide, our flagship nitric oxide generating anti-aging skin serum. The two most common nitric oxide supplements are L-arginine and L-citrulline. Find helpful customer reviews and review ratings for Juvenon BloodFlow-7 Blood Circulation Supplement Butch Booster BeetrootNitric Oxide Booster varicose Vein Optimizer Blood Pressure and Cholesterol Support Healthy Legs and feet 90 Capsules at Amazon. 00 ADD TO BAG. This policy is strictly policed to prevent abuse. Depending on the concentration, NO can induce biofilm dispersal, increase bacteria susceptibility to antibiotic treatment, and induce cell damage or cell death via the formation of reactive oxygen or. Bryan – NEW BOOK. Look for. By boosting N. Introduction. I get shaving burn daily. Auto-deliveries. Improve skin texture and moisture. the more you will save money. Copper as Dietary Supplement for Bone Metabolism: A Review. Backed by Nobel Prize-winning science & multiple gold standard clinical trials, Neo40 is a leading nitric oxide solution for heart health and is clinically-shown to deliver results! Neo40 helps: Support healthy blood pressure already in the normal range. 95. 4 out of 5 stars. . All makes a great treatment for one's face and neck. Story Rd #167843 Irving, Tx 75016. Bryan | Reduces Wrinkles & Fine Lines | 1. 00. (A) Norepinephrine, (B) dopamine, (C) serotonin, (D) acetylcholine, (E) glutamic acid, and (F) γ -aminobutyric acid (GABA) are small molecule neurotransmitters, where glutamic acid is also an amino acid neurotransmitter. In an era of increasing resistance rates to available antibiotics and subpar. Learn More. Nathan S. Reduce wrinkles and fine lines. Check price at Amazon. If everyone on your team is clear about your mission, vision, and values, it will be easier for them. NOW delivers a heavy dose of L-arginine, with 1000 mg of L-arginine HCL per capsule. 혈관확장은 건강한 혈압유지와 신체 구석구석에 영양분을 공급하기 위한 매우 중요한 과정으로 산화질소 (NO)는 발견 당시부터 혈관확장 화합물로서 인식 됐습니다. Pour one packet of N. ⓘ. 2021 Jun 29;13(7):2246. 4 Categories of Nitric Oxide Products. 1,355 likes · 4 talking about this. In such situations, instead of impaired NO synthase (NOS)-dependent NO generation, the entero. Revolutionize your skincare routine with the power of nitric oxide. VigRX Nitric Oxide. J. Nitric oxide (NO), an inorganic molecule, is generated endogenously by prokaryotes and eukaryotes from L-arginine and L-citrulline by a family of NO synthase enzymes (NOS; Table 1. Evidence of nitric oxide (NO) 1 synthesis by human skin cells was first reported just over 10 years ago [1]. School of Biosciences, Cardiff University, Cardiff, UK. In this narrative review, we aimed at elucidating the mechanisms behind the role of NO in the respiratory and cardio-cerebrovascular systems, in the presence of a. Blood flow is increased which allows more oxygen into tissues. In addition to creating Pneuma Nitric Oxide, he is the holder of more than a dozen issued U. The loss of Nitric Oxide over time is the catalyst for aging. That said, the more you stock up on, i. BENEFITS |. Dr. Our innovative formula uses an advanced delivery system that provides an exogenous source of Nitric Oxide that may support the following: Improve Nitric Oxide production. Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, approved by the Food and Drug Administration in 1999 at doses up to 80 parts per million. Introduction. In this installment of The Empowering Neurologist we are privileged to welcome Dr. N1o1 Nitric Oxide Activating Serum dramatically reverses the signs of N. "View Pneuma Nitric Oxide’s professional profile on LinkedIn. The capsules are made from proven natural extracts that are made precise for safe dosage. Said Dr. $136. Nitric oxide serum can be topically applied for many cosmetic purposes, and also has anti-inflammatory and ant-bacterial properties. Best Nitric Oxide Supplement for Women:. In turn, this provides benefits like increased energy, greater sexual stamina, lower blood pressure, better mood, and warmer hands and feet. After its. Get it Wednesday, Oct 25 . Derangement of NO production is implicated in the etiology of a multitude of dermatologic diseases, indicating future therapeutic directions. ) centers, of which the heme iron of cytochrome. Nathan Bryan Ph D. A novel nitric oxide generating serum is examined in this Pilot Study. . Verified Purchase. INDIANAPOLIS, Dec. Sign up. The Berkeley Life Heart Health Supplement is priced higher than most similar cardiovascular health supplements sold online today. It’s certified free of common allergens like gluten, soy, dairy, shellfish, and eggs, making it a good choice for people with food sensitivities and allergies. It consists of ingredients proven to increase nitric oxide production. ( 1) Studies have found nitrates to improve performance in both aerobic and. Progressive neuronal cell death leads to the characteristic changes that are observed clinically and measured both functionally and structurally [ 4, 9 – 11 ]. A recent multicenter international phase II clinical trial led by investigators at Massachusetts General Hospital (MGH) and the University of Alabama in Birmingham (UAB) has revealed that inhaled. Pneuma Nitric Oxide, LLC. Nitric oxide (NO) is one of the critical components of the vasculature, regulating key signaling pathways in health. Nitric oxide therefore acts as an endogenous regulator of the intracellular availability of oxygen in mammalian cells. New topical gel for erectile dysfunction. There are neuronal NOS (nNOS) along with endothelial (eNOS) and inducible NOS (iNOS). Protein: 1 gram. Materials and. Men's Grooming. e. 97 — available on subscription Add to cart; AGE-DEFIANCE SKINCARE SYSTEM $ 345. Clinically Proven. , “NO boosters”). Our body's nitric oxide production diminishes with age, as much as 50% by age 40, and continues to steadily decline. 1. com. By Dr. NITRIC OXIDE! The benefits of nitric oxide. Twice Daily. N1o1 by Pneuma Nitric OxidePneuma Nitric Oxide LLC. N1 O1 stimulates collagen production and restores the youthful flow of oxygen, hydration, and nutrients to your skin cells. According to the company, HumanN’s Superbeets product is rich in compounds naturally derived from beets that supposedly improve nitric oxide production, as well as heart health and. It contains his health by providing his body with vitamins and minerals. Bryan is a successful entrepreneur and Founder of HumanN, Inc, Pneuma Nitric Oxide, LLC, Nitric Oxide Innovations, LLC, Bryan Nitriceuticals, LLC and Bryan Therapeutics, Inc. Penile Enhancement Reviews. Up to 60 applications in each bottle. Nitric Oxide Serum. 30 ml $245. David Perlmutter, board certified neurologist and one of the first to recognize Alzheimer’s’ disease as a metabolic disease. USE BERKELEY TEST NITRIC OXIDE TEST STRIPS Saliva Nitric Oxide Test Strips are hand held strips that rapidly turn from white to deep pink based on the amount of a surrogate marker for Nitric Oxide. Obayashi, E. Outlook for Brands Juvenon BloodFlow-7 Reviews – Shocking Facts By The User . N1O1 sold through the health care practitioner channel will be re-branded under Berkeley Life in the spring. A nitric oxide generating, dual-chamber serum, has recently been developed (Pneuma Nitric Oxide, Austin, TX). Nitric Oxide Side Effects. . amp medical. 00 — available on subscription Add to cart; N1o1 Nitric Oxide Lozenges $ 79. In addition, our unique formulation contains a powerful antioxidant defense system that is safe for even the most sensitive skin. 31,32 Such destabilization of HIF-1α has been shown not to be. 30 ml $245. Include your return authorization number. David Perlmutter, board certified neurologist and one of the first to recognize Alzheimer’s’ disease as a metabolic disease. Citrus fruits. 00 ADD TO BAG. Introducing AMAZING INGREDIENTS with the Pneuma Age-Defying Gel Cleanser that joins natural cleansers with natural botanical ingredients. A novel NO-producing gel-formulation was tested beneficial in the treatment of acne vulgaris in an open-label pilot study using clinical evaluation. Nitric Oxide Activating AGE-DEFIANCE SKINCARE SYSTEM (4 products). sfexaminer. Besides its function as a diffusible messenger in the vasculature and in neurons, nitric oxide also plays a key role in innate immunity and inflammation. . 1,355 likes · 4 talking about this. The makers at Crazybulk claim Nitric-Max to help provide explosive energy and rapid muscle growth naturally. 20 years of research, clinically proven, doctor recommended. O. In 1998, the Nobel Prize in Physiology or Medicine was awarded to. They are the creators behind Pneuma Nitric Oxide and their latest line that we’re going to talk about today, which is the Activating Anti-Aging Nitric Oxide Skincare System. : Nitric oxide and its implications in skin homeostasis and disease –a review. Nathan S. Nearly 600,000 people have died. Nitric Oxide Innovations, Pneuma Nitric Oxide,Bryan Nitriceuticals and Nitric. Ignarro is one of three Nobel prize winners who discovered that our arterial cells produce nitric oxide and directly impact the functioning of arteries, the heart, and many other. Learn more . N1o1 is backed by 20+ years of research and technology from an. 33 / Count) See more About this item N1O1 NITRIC OXIDE LOZENGES: This nitric oxide generating. Nitric Oxide by Transparent Labs. In particular, a few studies have looked to see if nitric oxide nasal sprays can prevent. 1 In addition to its role as endothelium-derived relaxing factor (EDRF), NO serves many important biological functions in cardiovascular physiology. While your experience and intuition are also crucial components to confidently leading your business, if you aren. 2. Corrects Wrinkles, Tone, Clarity & Texture. Pneuma helped soothe my irritated skin and gave me an airbrushed complexion. Enhance the delivery of oxygen and nutrients to cells. Abstract. It claims to dilate the vessels and improves blood flow. Together, Dr. KEY POINTS: Nitric oxide is free radical gas. N1O1 Nitric Oxide Activating Serum is the FIRST age-defying skincare that uses a Nobel Prize-winning discovery to defy aging skin by correcting the cause of wrinkled and damaged skin. 00 ADD TO BAG . Best Nitric Oxide Supplement for Pump: Legion Performance Surge. 4 out of 5 stars 116 ratings. has built a brand of high perceived value. has built a brand of high perceived value. Our groundbreaking Nitric Oxide Activating skin care products provide unmatched benefits. Customer Reviews. Misc: Patient Sensing Technology • Low Air Loss Cover • Hospital Grade.